The fold from the nose to the corner of the mouth deepens as the cheek above it slides down, and a thread lift softens it by lifting the cheek rather than filling the fold. The first US clearance for PDO lifting threads names it in words, the treatment of moderate to severe nasolabial folds, and one maker's page lists the nasolabial folds with the jawline and neck. Two or three barbed threads a side, placed by our doctor under local anaesthetic in 30 to 60 minutes at PDO Threads Clinic, 8 Exhibition Road, with the plan in writing at a free consultation.
What it does on the folds
As the cheek tissue is drawn back towards the cheekbone, the weight comes off the fold and it softens. A fold that is deep because the cheek has lost volume needs filler as well, which our doctor can provide, and the doctor says which at the free consultation. In a 2026 randomised trial of 151 patients, 63% of those treated with a marketed PDO thread improved on the folds at seven months, and in the 62-patient clearance study 97% improved on a wrinkle severity scale at twelve weeks. The lift was gone by twelve months in the 160-patient series, which we say plainly.
The procedure and after
Local anaesthetic along each thread's path, small entry points at the hairline, each thread passed through a needle or a blunt cannula, drawn back to engage the barbs, trimmed and buried. Swelling and tightness for a week or two, a pull on smiling for the first days, bruising in some. Sleep on your back with the head raised for about a week, no wide mouth opening, hard food, massage or facials for one to two weeks, no dental treatment for two weeks. The how it works page sets out each step.
Who it suits
Adults aged about 35 to 65 with a fold that deepens as the cheek drops and skin with some spring. The usual exclusions apply: pregnancy and breastfeeding, an active infection, a bleeding disorder or blood thinners that cannot be paused, an autoimmune disease without the doctor's advice first, keloid scarring, recent dental work. The cheeks page covers the lift itself, and the full guide the rest.
Not sure you are suitable? Ask the clinician, it is free
Book a free consultation
Call PDO Threads Clinic on 0207 043 8107 or use the form below. The doctor looks at your folds at rest and moving, counts the threads, and gives you the plan in writing.

